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CHRISTOS D. GEORGIOU

CHRISTOS D. GEORGIOU

University of Patras, Greece

Dr. Christos Georgiou is Professor of Biochemistry at the University of Patras (since 2008). He has longstanding research links with the NASA Ames Research Center (Space Science and Astrobiology Division) in California, USA, the University of California at Santa Cruz (Departments of Biomolecular Engineering, and of Chemistry and Biochemistry), and the Desert Research Institute in Las Vegas, Nevada, USA. He was awarded a B.Sc. in Natural Sciences from Aristotelion University of Thessaloniki, Greece (in 1974), a M.Sc. in Biochemistry from Roosevelt University, USA (in 1979), and a Ph.D. in Molecular Biology-Biochemistry from Illinois Institute of Technology, USA (in (1985). He also pursued post-doctoral studies in the Biochemistry Department of the University of Illinois at Urbana-Champaign, USA, during 1985-1987.
 
His research interests are in the Biochemistry of Oxidative Stress as it relates to physiological and abnormal conditions of biological and medical interest. For these studies, his lab develops analytical biochemical methods for the in vivo/vitro quantification of various parameters of oxidative stress, which arethe following: (i) the reactive oxygen species (ROS) O2•− and Ë™OH free radicals (for their quantification also on the cellular levelthereare methods under development); the ROS-induced oxidative modification of (ii) DNA (quantification of small fragmented DNA; a quantitative counterpart of the qualitative Comet assay), (iii) lipids (quantification of their hydroperoxides or LOOH, and malondialdehyde or MDA) and (iv) proteins (quantification of their hydroperoxides or PrOOH, protein disulfides or PrSSPr, and protein-MDA adducts or PrMDA); another very important ROS oxidative modification in proteins is the generation of protein carbonyls, two new quantification methods for which have been already developed and are under publication. Finally, (v) a method has been developed for the multiparametric evaluation of thiol redox state (TRS) (quantification of 15 TRS parameters, including glutathione or GSHand oxidized glutathione orGSSG). Astrobiology is another important research interest, and includes the following areas: (i) An oxidative chemistry-oriented area that focuses on the development of methodologies for thein situ identification/quantification of photo/radiation-generated extraterrestrial soil ROS as potential oxidative stress-inducers of life inhibition, using as extraterrestrial (Mars)-like models deserts such as Atacama, Mojave, Antarctica etc. (ii) A life origin/detection-oriented area that focuses on the developmentof universal biomarkers for the identification of extraterrestrial life, and for determining the optimal conditions for the origin of terrestrial life.
 
 
Christos Georgiou is Professor of Biochemistry in the Department of Biology of the University of Patras, Greece. He received B.Sc. (1974) in Natural Sciences (Aristotelion University of Thessaloniki, Greece), M.Sc. (1979) in Biochemistry (Roosevelt University, USA), and Ph.D. (1985) in Molecular Biology-Biochemistry (Illinois Institute of Technology, USA). He pursued his post-doctoral studies (1985-1987) with Robert Gennis (Biochemistry Department of the University of Illinois at Urbana-Champaign, USA). His research is focused on the biochemistry of oxidative stress as it relates to physiological and abnormal conditions of biological and medical interest, and to the non-thermal effects of electromagnetic fields (Extra Low Frequency, ELF, 50 Hz) in organisms. For these studies, his lab develops analytical biochemical methods for the in vivo/vitro quantification of various parameters of oxidative stress and other relevant biological parameters. Astrobiology is another important research area, and includes the following topics: (1) Identification of photo/radiation-generated terrestrial/extraterrestrial soil reactive oxygen species as potential oxidative stress-inducers of microbial life inhibition, using as models Mars-like deserts such as Atacama, Mojave, and Antarctica. (2) Search for universal biomarkers crucial for (a) determining the optimal conditions for the origin of terrestrial life, and (b) the identification of extraterrestrial life. These astrobiology studies involve collaboration with NASA Ames Research Center (Space Science and Astrobiology Division, Moffett Field, California, USA), Search for Extraterrestrial Intelligence Institute (SETI; Mountain View, California, USA), Desert Research Institute (Las Vegas, Nevada, USA), and University of California (at Davis/Santa Cruz; Departments of Biomolecular Engineering, and Chemistry and Biochemistry).
 
 
198 words:
Christos Georgiou is Professor of Biochemistry in the Department of Biology of the University of Patras, Greece. He received B.Sc. (1974) in Natural Sciences (Aristotelion University of Thessaloniki, Greece), M.Sc. (1979) in Biochemistry (Roosevelt University, USA), and Ph.D. (1985) in Molecular Biology-Biochemistry (Illinois Institute of Technology, USA). He pursued his post-doctoral studies (1985-1987) in the Biochemistry Department of the University of Illinois at Urbana-Champaign, USA. His research is focused on the biochemistry of oxidative stressin relation to biological and medical abnormalities, and to the non-thermal effects of electromagnetic fields in organisms. For these studies, his lab develops analytical biochemical methods for the in vivo/vitro quantification of various parameters of oxidative stress. Astrobiology is another important research area, and includes the following topics: (1) Identification of cosmic/UVradiation-generated terrestrial/extraterrestrial soil reactive oxygen species as potential inhibitors of life, using Mars-like deserts and oxidants. (2) Search for universal biomarkers for (a) determining the optimal conditions for the origin of terrestrial life, and (b) the identification of extraterrestrial life. These studies involve collaboration with NASA Ames Research Center andSearch for Extraterrestrial Intelligence Institute(both in USA), Desert Research Institute (Las Vegas, USA), and University of California (Santa Cruz, USA).

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